Publications
Selected Original Research Articles
Boyd EK, Steenackers A, Rosenbalm KE, Proamer F, Doerfler PA, Eckly A, Hoffmeister KM, Falet H. PACSIN2 deletion impairs transferrin uptake and terminal erythroid maturation in mice. Blood Red Cells Iron. 2026;2(4):100128 | PMID: Pending
Biswas R,* Boyd EK,* Eaton N, Steenackers A, Schulte ML, Reusswig F, Yu H, Drew C, Kahr WHA, Shi Q, Plomann M, Hoffmeister KM, Falet H. PACSIN2 regulates platelet integrin β1 hemostatic function. J Thromb Haemost. 2023;21(12):3619-3632 (*equal contribution) | PMID: 37678551
Eaton N, Boyd EK, Biswas R, Lee-Sundlov MM, Dlugi TA, Ramsey HE, Zheng S, Burns RT, Sola-Visner MC, Hoffmeister KM, Falet H. Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice. Front Oncol. 2022;12:959806 | PMID: 36110936
Eaton N, Subramaniam S, Schulte ML, Drew C, Jakab D, Haberichter SL, Weiler H, Falet H. Bleeding diathesis in mice lacking JAK2 in platelets. Blood Adv. 2021;5(15):2969-2981 | PMID: 34342643
Eaton N, Drew C, Wieser J, Munday AD, Falet H. Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice. Haematologica. 2020;105(5):1414-1423 | PMID: 31296575
Grozovsky R, Jurak Begonja A, Liu K, Visner G, Hartwig JH, Falet H,* Hoffmeister KM.* The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015;21(1):47-54 (*equal contribution) | PMID: 25485912
Jurak Begonja A,* Pluthero FG,* Suphamungmee W, Giannini S, Christensen H, Leung R, Lo R, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WHA, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015;126(1):80-88 (*equal contribution) | PMID: 25838348
Bender M,* Giannini S,* Grozovsky R, Jönsson T, Christensen H, Pluthero FG, Ko A, Mullally A, Kahr WHA, Hoffmeister KM, Falet H. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015;125(6):1014-1024 (*equal contribution) | PMID: 25468568
Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011;118(8):2285-2295 | PMID: 21652675
Falet H, Pollitt AY, Jurak Begonja A, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010;107(9):1967-1979 | PMID: 20713593
Selected Review Articles
Falet H, Rivadeneyra L, Hoffmeister KM. Clinical impact of glycans in platelet and megakaryocyte biology. Blood. 2022;139(22):3255-3263 | PMID: 35015813
Grozovsky R, Giannini S, Falet H, Hoffmeister KM. Regulating billions of blood platelets: glycans and beyond. Blood. 2015;126(16):1877-1884 | PMID: 26330242
Falet H. New insights into the versatile roles of platelet FlnA. Platelets. 2013;24(1):1-5 | PMID: 22372530
Selected Book Chapters
Falet H. The platelet cytoskeleton. In: Platelet Physiology I: Volume 1, Platelets in Thrombotic and Non-Thrombotic Disorders, edited by Gresele P, López JA, Angiolillo DJ, Page CP. Springer, New York, NY; 2025. pp.359-376 | ISBN: 978-3-031-96340-7
Giannini S, Falet H, Hoffmeister KM. Platelet glycobiology and the control of platelet function and lifespan. In: Platelets, edited by Michelson AD, Cattaneo M, Frelinger AL, Newman PJ. Academic Press, Cambridge, MA; 2019. pp.79-97 | ISBN: 978-0-12-813456-6