People
Hervé Falet, PhD
Principal Investigator
MyNCBI | ORCID | LinkedIn | Twitter | Email
Hervé joined the Versiti Blood Research Institute and Medical College of Wisconsin faculty in 2016 and was promoted to Investigator the following year. His primary research interests are associated with deciphering the cellular mechanisms and proteins regulating normal and abnormal blood platelet production and function.
Hervé received his MS in Molecular Pharmacology in 1993 and completed his PhD in Molecular and Cellular Biology in 1997 from Paris Descartes University in the laboratory of Dr Francine Rendu. His work focused on the role of the protein tyrosine phosphatase SHP-1 in platelet signaling and activation. His research was supported by fellowships from the French Ministry of Higher Education and Research and the Medical Research Foundation.
For his postdoctoral fellowship, Hervé joined the laboratory of Dr John Hartwig at Brigham and Women’s Hospital and Harvard Medical School. His research was associated with elucidating the role of cytoskeletal and scaffolding proteins, i.e., Wiskott-Aldrich Syndrome protein (WASp), WASp-interacting protein (WIP), the Arp2/3 complex, and filamin A (FlnA) in platelet production, function, and survival. Mice lacking WASp or its partner WIP develop mild thrombocytopenia with increased platelet clearance. FlnA anchors the Von Willebrand Factor receptor subunit GPIbα to the actin cytoskeleton and regulates signaling via the collagen receptor GPVI through a direct interaction with the protein tyrosine kinase Syk. Mice specifically lacking FlnA in megakaryocytes produce large and fragile platelets that function and circulate poorly.
His current studies focus on the cellular mechanisms and proteins regulating the extensive and unique intracellular membrane rearrangements that accompany megakaryocyte maturation and platelet production. His recent work defined two endocytic proteins, the F-BAR protein PACSIN2 and the large GTPase dynamin 2, as major players in the formation of the megakaryocyte demarcation membrane system.
Emily Boyd, MS
PhD Student
Emily is a Medical College of Wisconsin PhD candidate who joined the Falet Lab in February 2022 to complete her dissertation. She received her Bachelor of Science degree in Neuroscience from the University of Michigan and received a Master of Science in Human Nutrition from Columbia University. Emily primarily studies endocytosis in megakaryocytes and platelets, focusing on the role of PACSIN2 and dynamin 2. In her free time, she enjoys watching films and skateboarding.
Students, Clinical/Research Fellows, and Faculty Mentored
High School Students
Nina Smolyar, Boston Latin School, Boston, MA, 1997–1998
Lazaro Vergara, Marquette University High School, Milwaukee, WI, 2017–2018
Lucia Rondini, University School of Milwaukee, Milwaukee, WI, 2018–2019
Anastasia Finley, University School of Milwaukee, Milwaukee, WI, 2022–2023
Undergraduate Students
Aileen Tiro, Boston University, Boston, MA, 1999–2000
Silke Ebbing, Ruhr University Bochum, Bochum, Germany, 2002–2003
Olivia Gaumétou, LaSalle Beauvais Polytechnic Institute, Beauvais, France, 2007–2008
Delphine Simon, LaSalle Beauvais Polytechnic Institute, Beauvais, France, 2007–2008
Thomas Bertin, LaSalle Beauvais Polytechnic Institute, Beauvais, France, 2008–2009
Guillaume Sertour, LaSalle Beauvais Polytechnic Institute, Beauvais, France 2009–2010
Max Adelman, Cornell University, Ithaca, NY, 2009–2010
Emily Legan, Marquette University, Milwaukee, WI, 2016–2017
Eric Fellin, Marquette University, Milwaukee, WI, 2017–2018
Gabrielle Gooding, University of Wisconsin–Milwaukee, Milwaukee, WI, 2022–2023
Medical Students
Gregory Chang, Harvard Medical School, Boston, MA, 2000–2002
> Currently Professor, New York University Grossman School of Medicine, New York, NY
Harry Gebhard, Ludwig Maximilian University Munich, Munich, Germany, 2004–2005
> Currently Team Leader, Canton Hospital Basel-Land, Liestal, Switzerland
Amalie Dahl Haue, University of Copenhagen, Copenhagen, Denmark, 2013–2014
> Currently Postdoctoral Researcher, University of Copenhagen, Copenhagen, Denmark
MSc Students
Marc-Olivier Nallet, Paris Descartes University, Paris, France, 1994–1995
Sabine Pain, Paris Descartes University, Paris, France, 1995–1996
Abdelhafid Saci, Paris Descartes University, Paris, France, 1996–1997
Anna Hendeby, University of Gothenburg, Gothenburg, Sweden, 2005–2006
Galia Askarieh, University of Gothenburg, Gothenburg, Sweden, 2006–2007
Terese Jönsson, University of Gothenburg, Gothenburg, Sweden, 2010–2011
Shabnam Rezaie-Aval, University of Gothenburg, Gothenburg, Sweden, 2011–2012
Julia Sjödin, University of Gothenburg, Gothenburg, Sweden, 2012–2013
Nadia Jaber, University of Gothenburg, Gothenburg, Sweden, 2013–2014
Behshte Azizi, University of Gothenburg, Gothenburg, Sweden, 2013–2014
Emel Ahmet, University of Gothenburg, Gothenburg, Sweden, 2014–2015
Demetra Korkos, Medical College of Wisconsin, Milwaukee, WI, 2019–2020
Allison Gerk, Medical College of Wisconsin, Milwaukee, WI, 2020–2021
PhD Students
Emma Josefsson, University of Gothenburg, Gothenburg, Sweden, 2003–2007
Viktoria Rumjantseva, University of Gothenburg, Gothenburg, Sweden, 2005–2009
Nathan Eaton, Medical College of Wisconsin, Milwaukee, WI, 2017–2021
Emily Boyd, Medical College of Wisconsin, Milwaukee, WI, 2021–present
PhD Student Committees
Anusha Rengarajan, Medical College of Wisconsin, Milwaukee, WI, 2022–present
Hongyin Yu, Medical College of Wisconsin, Milwaukee, WI, 2023–present
Postdoctoral Researchers
Antonija Jurak Begonja, University Hospital of Würzburg, Würzburg, Germany, 2007–2014
> Currently Associate Professor, University of Rijeka, Rijeka, Croatia
Hugh Kim, University of Toronto, Toronto, Canada, 2011–2013
> Currently Associate Professor, Centre for Blood Research and University of British Columbia, Vancouver, Canada
Markus Bender, University Hospital of Würzburg, Würzburg, Germany, 2012–2014
> Currently Professor, University of Würzburg, Würzburg, Germany
Melissa Lee-Sundlov, Versiti Blood Research Institute, Milwaukee, WI, 2015–2022
Leonardo Rivadeneyra, Versiti Blood Research Institute, Milwaukee, WI, 2017–2022
Waseem Anani, Versiti Medical Sciences Institute, Milwaukee, WI, 2018–2020
> Currently Medical Director, University of Utah School of Medicine, UT
Ratnashree Biswas, Versiti Blood Research Institute, Milwaukee, WI, 2019–2024
Daniel Afosah, Virginia Commonwealth University, Richmond, VA, 2023–2024
Faculty
Renata Grozovsky, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 2009–2016
Silvia Giannini, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 2010–2016
Faculty Committee
Mitchell Dyer, Medical College of Wisconsin, Milwaukee, WI, 2023–present